Presenter: Paulo Cesar De Morais
Affiliation: Catholic
University of Brasília
Event: 2nd Edition of International Congress on Materials Science andNanotechnology (M-Nano 2026)
Tittle:
Cell viability assays
under radiofrequency application modulated by nanomaterials
📅 Conference Dates: November 23–25, 2026
📍 Venue: Singapore & Online
🌐 Website: https://materials.miconferences.com/
🧪 Understanding the Research Focus
Nanomaterials
are increasingly being explored as modulators of cancer therapies. When
combined with external stimuli such as radiofrequency (RF), engineered nanocomposites
may significantly enhance therapeutic efficacy while maintaining baseline
biocompatibility.
This
keynote explores how cell viability assays can quantitatively evaluate
antitumor responses when nanomaterials are combined with RF exposure.
📊 Quantitative Modeling Approach
The
presentation applies the Hill model to analyze cell viability data,
enabling determination of:
- Benchmark Dose (BMD)
- Lethal Dose 50 (LD50)
- Cooperativity coefficient
(E)
- Dissociation constant (K)
This
mathematical framework provides deeper insight into dose–response relationships
and nanomaterial-mediated cytotoxicity under RF stimulation.
🔬 Nanocomposite Strategy
Special
emphasis is placed on graphene-based nanocomposites, particularly:
Graphene
oxide (GO) functionalized with polyethyleneimine (PEI) and decorated with gold
nanoparticles (GO-PEI-Au).
Tumor
cell lines evaluated include:
- LLC-WRC-256
- B16-F10
Results
demonstrate that while GO-PEI-Au exhibits relative biocompatibility in the
absence of radiofrequency (nRF), the application of RF dramatically enhances
cytotoxicity — increasing tumor cell death by orders of magnitude.
🌟 Key Takeaway
The
synergistic combination of radiofrequency therapy with engineered nanomaterials
represents a promising direction in cancer treatment.
RF-triggered
enhancement of nanocomposite-mediated cytotoxicity supports future
translational research, including validation in tumor-bearing animal models.
👨🔬 About
the Speaker
Paulo César De Morais, PhD, is an
internationally recognized physicist and nanotechnology researcher with
extensive contributions to materials science and biomedical applications. He
served as Full Professor of Physics at University
of Brasília until 2013 and was subsequently appointed Emeritus Professor
in 2014. He has also held distinguished international academic appointments,
including Visiting Professor at Huazhong
University of Science and Technology (2012–2015), Distinguished
Professor at Anhui University (2016–2019),
and Full Professor at Catholic University of
Brasília since 2018.He has published more than 500 scientific papers, delivered over 200
international invited talks, holds 15+ patents, and has accumulated more than
13,000 citations.
🌍 Join M-Nano 2026
🔗 Abstract Submission: https://materials.miconferences.com/abstract-submission
🔗 Register: https://materials.miconferences.com/register
🔗 Contact: https://materials.miconferences.com/contact
📧 materials@mathewsconference.com
📞 +1 (312) 462-4448
💬 WhatsApp: +1 (424) 377-0967
No comments:
Post a Comment